Ketamine has “shown promise” in the rapid treatment of major depression and suicidal thoughts, a US study says.

Ketamine has a reputation as a party drug but is licensed as an anesthetic.

The study found the use of the drug via a nasal spray led to “significant” improvements in depressive symptoms in the first 24 hours.

The Royal College of Psychiatrists said it was a “significant” study that brought the drug “a step closer to being prescribed on the NHS”.

The report by researchers from Janssen Research and Development, a Johnson and Johnson company, and Yale School of Medicine, is the first study into ketamine as a treatment for depression that has been done by a drug company.

It is being published in the American Journal of Psychiatry.

The trial looked at 68 people at imminent risk of suicide.

All patients were treated with a stay in hospital and anti-depressants.

In addition, half were given ketamine in the form of esketamine (part of the ketamine molecule) in a nasal spray and half were given a placebo.

The study found those using esketamine had a much greater improvement in depression symptoms at all points over the first four weeks of treatment.

However, at 25 days the effects had leveled out.

The study’s authors suggest it could offer an effective rapid treatment for people severely depressed and at imminent risk of suicide and could help in the initial stages of treatment, as most anti-depressants take four to six weeks to become fully effective.

The nasal spray is now undergoing phase three trials before it can be licensed for treatment.

Potential for abuse

There were no reports of esketamine dependence or misuse in the trial but the authors warn that more research is needed on the potential for abuse of ketamine and say these should be looked at during subsequent trials.

Scientists in the UK are also studying ketamine as a treatment for depression taken intravenously.

Dr. James Stone, from the Royal College of Psychiatrists, told the BBC the “interesting” US study confirmed the findings from successful studies into intravenous ketamine.

“The main reason for its significance is because this is being developed by a drug company and it’s potentially quite likely that this medication might become available as a treatment available on the NHS for depression.”

‘Severe depression’

He said because it was being given as a nasal spray it was “much easier to administer” than intravenous ketamine and was “potentially quicker to give, so it means more people can be dosed at the same time” and you need less equipment.

Dr Stone said if it did go on to be prescribed on the NHS it would be aimed at people with severe depression as a second or third line of treatment if other drugs haven’t worked and could be used for people instead of electroconvulsive therapy.

Prof Mitul Mehta from King’s College told the BBC it was an “exciting” study.

“All the studies to date have been looking at intravenous use – there are some people who have explored oral ketamine but that doesn’t appear to be as successful as intravenous so intranasal seems to be a really good halfway-house.

“It enters the body relatively quickly – it’s not as fast as going straight into your bloodstream but not as slow as via the stomach and it’s reasonably easy to control how much you give to a person. In that respect this is a really important study.”

But he said far bigger studies are needed to look out for any rare side-effects.

original article https://www.bbc.com/news/health-43753073

 

Candy Olandt

Chief of Staff

My role with Revitalist is one of providing a high level of administrative support, communication and relationship building between our CEO, Staff and other key Stakeholders.

Day to day responsibilities are listed, but not limited to the following:

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Amanda Deleon

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As the Revitalist human resources (HR) coordinator my professional administrative duties include being a liaison between employees and our benefits vendors and as the corporate resource for the employees.  I facilitate and coordinate with recruitment (hire to retire), maintain employee records, assist with payroll processing and provide administrative support to all employees.

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Ashley Brooks

I manage the Revitalist Athena EMR for front desk employees, clinical staff, therapists, and providers. Each clinic is different in its specific needs so I customize our EMR to what is needed to effectively run each clinic. I provide both in-person and virtual Athena training as needed. If any changes are needed for your specific location’s tablespace, please let me know. Email is the best way to reach me. 

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Again, this is what will come in the initial start up order for your clinic, but if you have other specific requests, please let me know. 

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I offer mentorship and guidance for other lead CRNAs as they mature in their role as clinic leads.

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Deana Ferguson

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Grant Whitfield

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If there are any issues with the printer, internet, wireless access, computer/laptop, phone, etc., send an email to Novatech at ticketupdate@novatech.net or call (800) 264-0637 and copy Grant so he can monitor progress.

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If there are any issues with your clinic, like plumbing, electrical, HVAC, etc., send an email to Grant, and he’ll contact the landlord to work through who will handle the issue/s. If the issue is not under the landlord’s scope, he will contact an appropriate company to complete the work and introduce the lead CRNA for coordination purposes.

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