Two new studies suggest the psychiatric benefits of ketamine treatment may extend beyond just the targeting of depression. The research demonstrates ketamine may be helpful in targeting both anxiety- and substance abuse-related depression.

Although ketamine is a relatively old drug, originally developed in the 1950s as an anesthetic, over the last decade a growing body of research has affirmed its unique, and rapid, antidepressant effects. The anecdotal effects of the drug on depression have raced ahead of scientific research so quickly that ketamine clinics have popped up all across the United States, where the drug can be administered for up to US$1,000 a dose.

Much is still unknown about how efficacious ketamine actually is for depression. We don’t know ideal dosages, how long the treatments last, or how safe long-term usage is. Two newly published studies are adding to our knowledge about ketamine’s psychiatric uses, adding weight to the drug’s burgeoning new potential.

The first study, led by a team from Massachusetts General Hospital and Harvard Medical School, set out to study how effective ketamine is at treating patients with anxiety-based treatment-resistant depression. This is an important question to resolve, as many traditional antidepressants do not consistently improve anxiety-based symptoms in cases of major depression.

The study took 99 subjects with treatment-resistant depression, half of whom suffered from high anxiety and half of whom displayed no anxious symptoms. The study randomly administered subjects either one of four different intravenous ketamine doses, or midazolam, a general sedative that could serve as a control.

As well as demonstrating ketamine’s novel antidepressant qualities, the study revealed the drug worked equally well in both anxious and non-anxious subjects. This suggests that ketamine’s antidepressant effects are uniquely effective across different types of treatment-resistant depression, something that cannot be said for many major antidepressant drugs.

“In contrast to reports from monoaminergic antidepressants, our data suggest that patients with anxious depression respond equally as well to ketamine compared to those with non-anxious depression,” write the researchers in the published study.

The second new study comes from a team at Yale University School of Medicine. This research investigated whether ketamine could be effective in treating addiction-related depression when administered in tandem with naltrexone.

A study in 2018 offered a small but significant finding, revealing that ketamine was ineffective in treating depression when administered alongside naltrexone. These results were important because they suggested that part of ketamine’s antidepressant effects may be related to the activation of opioid receptors, which would mean long-term ketamine use may potentially result in problems with addiction, something that many researchers have long argued against.

Naltrexone, an opioid receptor blocker, is often administered effectively to combat serious substance abuse problems, so if it rendered ketamine ineffective then that would cast doubt on much research into how ketamine actually works to reduce symptoms of depression. The new Yale research was small, with a sample of only five patients, but its results strongly suggest ketamine and naltrexone do not cancel each other out.

All five subjects suffering from alcohol use disorder and depression displayed significant depressive relief from ketamine dosages despite long-term naltrexone consumption. Senior author on the study, John Krystal, says although larger studies still need to be completed the research does suggest ketamine and naltrexone may be a complimentary combination that helps treat substance abuse and its related depression.

“[The results] raise the possibility that for people who have depression complicated by substance abuse disorders, the combination of ketamine and naltrexone may be a strategy to explore in the effort to optimally treat both conditions,” says Krystal.

Although this new study only consisted of five subjects, the prior research linking ketamine to the opioid system was generated from just 12 subjects. So we are still in uncharted territory regarding ketamine’s mechanistic effects of the brain. But the Yale research should assuage some fears that ketamine may be, “merely another opioid in a novel form.”

The ketamine anxiety study was published in the journal Depress Anxiety.

The ketamine naltrexone study was published in the journal JAMA Psychiatry.

Source: Yale News

Candy Olandt

Chief of Staff

My role with Revitalist is one of providing a high level of administrative support, communication and relationship building between our CEO, Staff and other key Stakeholders.

Day to day responsibilities are listed, but not limited to the following:

Support and maintain the CEO’s calendar of events and meetings.

Attend meetings, take notes and disseminate pertinent information accordingly.

Support the CEO with email correspondences.

Support CEO, Executive Team, Lead CRNAs and other key Staff Members in the preparation of weekly staff meetings and communications.

Work closely with the CEO, Executive Team, Lead CRNAs and other key stakeholders to help drive strategic business planning, and support growth initiatives.

Act as a liaison for the CEO with the Lead CRNAs and other key Stakeholders.

Collaborate with CEO, Lead CRNAs, Executive Team and other key Stakeholders to help strategic ideas get off the ground, and provide early facilitation until a more formal project is established.

Act as a trusted advisor and brainstorming partner to the CEO, Executive Team, Lead CRNAs and other key Staff Members.

Proactively address pressing issues by calling them to the attention of the appropriate decision-maker and help to identify potential solutions.

Amanda Deleon

HR Service Coordinator

As the Revitalist human resources (HR) coordinator my professional administrative duties include being a liaison between employees and our benefits vendors and as the corporate resource for the employees.  I facilitate and coordinate with recruitment (hire to retire), maintain employee records, assist with payroll processing and provide administrative support to all employees.

Director of Admin Services at Revitalist

Ashley Brooks

I manage the Revitalist Athena EMR for front desk employees, clinical staff, therapists, and providers. Each clinic is different in its specific needs so I customize our EMR to what is needed to effectively run each clinic. I provide both in-person and virtual Athena training as needed. If any changes are needed for your specific location’s tablespace, please let me know. Email is the best way to reach me. 

Administrative services
Branding Services

I work directly with Fleetwood Photo in Knoxville with all our clinic orders. I order each clinic an initial start-up of items and they will be shipped directly to your clinic. When you are running low please email me your requests. Please allow 3-4 weeks for delivery.

Again, this is what will come in the initial start up order for your clinic, but if you have other specific requests, please let me know. 

Director of Insurance Services at Revitalist

Priscilla Bullock

Courtney Hobby

How May We Help?

Auditor at Revitalist

Jessi Shattuck

Insurance Specialist at Revitalist

Adrienne Worley

How May We Help?

Nicholas Kalynych

Lead CRNA - Jacksonville, Florida

I offer mentorship and guidance for other lead CRNAs as they mature in their role as clinic leads.

Chief Development Officer

  • Provide a conduit to Revitalist corporate as a point-of-contact and liaison for prospective CRNAs and clinic owners
  • Consultation for administrative, operational, and financials in development and hardwiring our corporate infrastructure
  • Guidance structure with policy development
  • Mentorship and resource to clinic lead CRNA
  • Director of Compliance and Risk Management
  • Director of HR
  • Chairperson of the AAP Conference
  • Advisory Board Member

Director of HR

I am responsible for the planning, development, and oversight of the policies, activities, and staff of the Human Resource (HR) department; I act as corporate liaison to CBiz (our corporate partner-benefits provider). Duties as assigned and the following:

  • Plan, direct, and manage all HR initiatives, such as recruitment, compensation, benefits, training, and employee relations.
  • Implement fair employment practices.
  • Advise lead managers and employees and labor policies, such as ADA, FMLA, etc.
  • Helping develop employee engagement, feedback, compliance, and facilitate performance management.
  • Networking with veteran organizations, universities and colleges, behavioral health and anesthesia communities, and other health sectors to facilitate relationships and partnering opportunities.
Director Integrative SVCS at Revitalist

Deana Ferguson

I am responsible for the development and oversight of the behavioral health programs at Revitalist, which includes the following components:

Grant Whitfield

IT Support

If there are any issues with the printer, internet, wireless access, computer/laptop, phone, etc., send an email to Novatech at ticketupdate@novatech.net or call (800) 264-0637 and copy Grant so he can monitor progress.

Security System

If there are any issues with your CPI-managed security system, send an email to Karen Fusaro at kfusaro@cpisecurity.com or call (800) 948-7133 ext. 6250 and copy Grant so he can monitor progress.

Clinic/Maintenance Issues

If there are any issues with your clinic, like plumbing, electrical, HVAC, etc., send an email to Grant, and he’ll contact the landlord to work through who will handle the issue/s. If the issue is not under the landlord’s scope, he will contact an appropriate company to complete the work and introduce the lead CRNA for coordination purposes.

General Liability & Malpractice

If you have any questions about a policy or need help adding an additional insured, etc., send an email to Grant, who will contact Liz Rafferty (erraferty@cbiz.com) and AnneMarie Pirelli (annemarie.pirelli@cbiz.com) to handle the task.

Water Stations

If you have any questions about a policy or need help adding an additional insured, etc., send an email to Grant, who will contact Liz Rafferty (erraferty@cbiz.com) and AnneMarie Pirelli (annemarie.pirelli@cbiz.com) to handle the task.

Call Us
Consultation